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How Food Preservatives Make You Fat

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It’s no secret that we’ve become a heavy population. Changes to our food supply—with our heavy reliance on packaged and processed foods—may have something to do with it. If you were never a stickler about reading food labels, you will be after reading what two common food stabilizers do to your gut and your body…

The additives in question are emulsifiers—a type of food additive that helps maintain food texture. Before sharing the latest research on what these emulsifiers are doing to your gut, weight and health, though, here’s some background on what is normally supposed to happen in your gut, and it centers on the gut microbiome.

THE GOOD AND THE BAD ABOUT BACTERIA

The gut microbiome is the universe of trillions of microbes that call your intestinal tract home and that allow you to thrive by, for example, processing nutrients and arming your immune system. These gut bacteria are helpful and protective so long as they’re contained within the gut. If they cross the epithelium (the porous lining of the intestine) and pass into the bloodstream, problems can occur. Mother Nature’s defense against this is the mucous membrane—thick layers of mucus lining the intestine.

Anything that chips away at the mucous membrane or changes the way it works can, for one, increase the risk of obesity and also increase the risk of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Both of these, along with obesity, in turn, increase the risk of colon cancer.

Researchers have suspected that emulsifiers damage the gut, allowing bacteria to cross the delicate epithelium and set off a chain reaction that can lead to weight gain, metabolic syndrome (the triad of high cholesterol, high blood pressure and diabetes) and/or inflammatory bowel disease. So researchers used mice in a series of experiments to learn more about what two of the most commonly used food emulsifiers do to the intestinal tract. Their names may be quite familiar to you from reading food labels—carboxymethylcellulose (also known as cellulose gum) and polysorbate-80.

THE FATE OF EMULSIFIED MICE—IS IT YOURS?

For 12 weeks, mice were either given drinking water that was mixed with one of the two emulsifiers at concentrations similar to real-world human consumption…or plain water.

The results: Bacteria in mice that drank emulsifier-spiked water could be found clinging to the intestinal epithelium. The mucus barrier was much thinner in most of the mice consuming emulsifiers compared with mice that drank plain water…and they also had a different mix of bacteria than the mice that drank plain water. Carboxymethylcellulose and polysorbate 80 each caused the same type and degree of change to the gut epithelium, mucous membrane and gut microbiome.

Why this matters: Mice that drank emulsifiers ate more and so gained more weight. They also become glucose intolerant, setting them up for diabetes and metabolic syndrome. And the altered mix of bacteria in their gut promoted intestinal inflammation.

The researchers then toyed with the amount of emulsifiers given to the mice to see just how little it takes for the microbiome to react. Just one half of the equivalent amount of carboxymethylcellulose permitted by the FDA for humans led to low-grade inflammation and increased fat. Just one tenth of the amount permitted by the FDA led to weight gain and glucose intolerance. And when the research team switched the experiment by adding emulsifiers to food instead of water, the results were the same.

The study’s authors were quick to point out that this study doesn’t defy the notion that eating and drinking too much is responsible for weight gain and metabolic syndrome. What it does show is that food additives may be contributing to obesity and intestinal inflammation and the range of problems that come with these conditions. Surely, the study findings amp up the incentive to carefully read the label of any packaged food item you plan to put in your mouth.

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Source: Source: Study titled “Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome,” from researchers in the department of biology, Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences at Georgia State University in Atlanta, published in Nature. Date: April 14, 2015 Publication: Bottom Line Health
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