It is increasingly clear that the ubiquitous chemical bisphenol A (BPA)—commonly found in food and drink packaging, plastic products, cans and even paper—is bad for just about everybody. But a recent study suggests that women with certain hormonal problems may be especially vulnerable to BPA’s harmful effects. At risk: Women with polycystic ovary syndrome (PCOS), an endocrine disorder characterized by excessive production of androgens (male sex hormones). PCOS can lead to excessive facial and body hair, acne, weight gain, ovulation irregularities, infertility and increased risk for diabetes and heart disease.
Study findings: BPA blood levels were about 45% higher, on average, in PCOS patients than in women who did not have this endocrine disorder. Also, as BPA levels increased, so did levels of testosterone and other androgens.
Theory: It’s a vicious cycle. Excessive secretion of male sex hormones interferes with the liver’s ability to detoxify BPA, thus further contributing to an accumulation of BPA in the blood…and then the BPA itself appears to interfere in several ways with the normal production, metabolism, action and interaction of various hormones, including androgens.
Researchers noted that more studies in humans are needed. In the meantime, while everyone would be wise to avoid BPA, it seems that PCOS patients should take special care to limit their exposure to this chemical. Editor’s note: For guidelines, check out another HealthyWoman from Bottom Line article, “The New Threat from BPA…and How to Keep This Toxic Chemical Out of Your Food.”
